The purpose of the study was to examine the role of women empowerment and poverty eradication in Kyenjojo district. The objectives of the study were: to find out the role of women empowerment and poverty eradication in Kyenjojo district; (ii) to identify the challenges affecting women empowerment in Kyenjojo district; (iii) to suggest possible solutions to the challenges affecting women empowerment and poverty eradication in Kyenjojo district. The researcher adopted a cross- sectional research design for the study. The study used questionnaire and interview guide to obtain data from all officials and interviews from women groups and household heads. In all, 191 respondents were selected through purposive, and simple random sampling techniques. Data was collected by using interviewing, observation and questionnaire methods. Statistical analysis was done using Statistical Package for Social Scientists (SPSS 16.0) and Microsoft excel 2007.The study concludes that women empowerment has promoted self-employment, reduced gender-based violence in most families, and reduced on the level of income inequality. Women empowerment was found to be facing a number of challenges like low levels of income, low levels of mobilization and weak leaders. The study also concludes that there is need to reduce on interest rates and mortgage on loans for women as a solution to the challenges facing women empowerment in the district. There is still need to support women through sensitization meetings and workshops. The study, among other things, recommended that government should team up with the local rural banks to negotiate for low interest rate and flexible payment terms to encourage more women to acquire more loans for their businesses.