This study examined the relationship between agriculture support programs and poverty eradication in Ntusi Subcounty, Sembabule District, Uganda. The research was guided by three specific objectives: to assess the influence of input support programs on poverty eradication; to examine the effect of extension services and farmer training on poverty eradication; and to determine the role of access to credit and financial services on poverty eradication. A cross-sectional research design was adopted, combining both quantitative and qualitative approaches. Data were collected from 120 respondents comprising farmers, agricultural extension workers, local government officials, and community leaders using structured questionnaires, interview guides, and focus group discussions. The findings revealed that input support programs significantly improved agricultural productivity and household incomes among beneficiary farmers. Extension services and farmer training were found to have a positive and statistically significant effect on farming practices and poverty reduction. Access to credit and financial services was identified as a critical enabler of agricultural investment and economic advancement among rural households. The study concluded that agriculture support programs played a vital role in reducing poverty levels in Ntusi Sub-county when effectively implemented and coordinated. It was recommended that government agencies, non-governmental organizations, and development partners strengthen and sustain agriculture support interventions to achieve lasting poverty eradication in rural Uganda.