This study examined the relationship between e-procurement systems and organizational performance at Century Bottling Company in Namanve, Kampala City, Uganda. Using a descriptive correlational research design, data was collected from 87 respondents through structured questionnaires and analyzed using SPSS version 25. The findings revealed a significant positive relationship (r=0.742, p<0.01) between e-procurement system implementation and organizational performance. The study concluded that e-procurement systems substantially improved procurement efficiency, reduced operational costs, enhanced transparency, and positively impacted overall organizational performance. Recommendations included investing in advanced e-procurement technologies, providing continuous staff training, and integrating e-procurement systems with existing enterprise resource planning systems.