The study set out to establish the effects of Domestic Violence on academic performance in secondary schools in Nansana Municipality, Wakiso District. The study was guided by the following objectives; finding out the forms of domestic violence on academic performance in secondary schools in Nansana Municipality, establishing the effects of domestic violence on the academic performance in secondary schools and analyzing the ways of mitigating domestic violence as to improve on academic performance in Nansana Municipality. The study adopted a descriptive research design employing both qualitative and quantitative approaches that targeted; parents, head teachers, teachers, learners and community leaders who were expected to provide the required information. Questionnaires, interview guide and observation checklists were to collect data from various respondents. To get quality data, the researcher ensured that the instruments were valid by conducting a preliminary survey and SPSS to determine their reliability. The findings from the study indicated that domestic violence affecting academic performance in secondary schools in Nansana Municipality is in different forms and greatly hinders the learners’ progress and success, much as several attempts have been made to mitigate it. The researcher therefore recommended; awareness campaigns for domestic violence, enforcement of the law and advocacy for human rights, the teaching of Christian religious education to be compulsory as a strategy for moral formation. The church should also intensify its mission out to the people as a way of correcting human error and restoring peace, love, care and harmony in society.