This study investigated the socio-economic status of parents and the level of household welfare in Muramba Sub County, Kisoro District, and examined the relationship between these two variables. Using multiple linear regression analysis, the study found that parental socio-economic status was significantly influenced by education level, occupation type, and household income, with education having the strongest effect. These factors explained over 61% of the variation in socio-economic status among parents. Similarly, household welfare was positively associated with access to health services, education of the household head, housing quality, and asset ownership, with housing quality and asset ownership emerging as the most significant predictors. This model accounted for approximately 67% of the variance in household welfare. Furthermore, the study revealed a strong and positive relationship between parental socio-economic status and household welfare, where higher socio-economic status predicted better welfare outcomes. Household size and distance to social services negatively influenced welfare. The findings indicated that education, economic empowerment, access to services, housing conditions, and infrastructure are critical determinants of socioeconomic and welfare outcomes in the community. The study concluded that improvements in parental education, economic opportunities, and access to essential services are vital for enhancing household welfare in Muramba Sub County. There should be deliberate efforts to expand educational opportunities for both adults and children, promote skills training and microfinance access, improve health service availability, and enhance housing and infrastructure conditions.